In the distant future, humanity has found a way to live forever by purchasing mechanical bodies, but this way to immortality is extraordinarily expensive. An impoverished boy, Tetsurou Hoshino, desires to purchase a pass on the Galaxy Express 999—a train that travels throughout the universe—because it is said that at the end of the line, those aboard can obtain a mechanical body for free. When Tetsurou's mother is gunned down by the villainous machine-man hybrid Count Mecha, however, all seems lost. Tetsurou is then saved from certain death by the mysterious Maetel, a tall woman with blonde hair and a striking resemblance to his mother. She gives him a pass to the Galaxy Express under one condition: that they travel together. Thus, Tetsurou begins his journey across the universe to many unique planets and thrilling adventures, in hopes of being able to attain that which he most desires. [Written by MAL Rewrite]

The half-divine King of Uruk, Gilgamesh, was considered but a paltry legend... until his majestic tomb was discovered in the Middle East. This imperial crypt drew scientists from across the globe to the land, and with that came recognition of their fame. In a joint effort, they built Heaven's Gate in pursuit of advancing human knowledge. One day, a group of terrorists driven by greed attack Heaven's Gate, causing an explosion within the facility for archaeological excavation. The resulting phenomenon had much more impact than anyone could have imagined. More specifically, it triggered the birth of supernatural beings. In the midst of this mess, two siblings by the names of Kiyoko and Tatsuya encounter mysterious men with supernatural powers who, despite the scientific crisis around them, claim the ability to restore good to the world. Nevertheless, these seemingly heroic and all-powerful creatures act under the rule of factions. Are they here to save the world, or destroy it?

A dog named Weed happens to hear that he is the son of Gin, the great leader of Ohu who lead the dogs of Ohu to victory in a fight against monsterous bear, Akakabuto. Weed wants to find his father no matter what. On a journey to find his father Weed meets many friends and enemies. (Source: ANN)

Based on a short section of the novel Cuore by the Italian Edmondo de Amicis, Marco is a young boy living in Genoa, Italy, together with his father Pietro. But the family is not complete, for Marco`s mother left for Argentina around a year earlier in order to find work. Letters from her arrive regularly until one day they suddenly stop. Worry for his mother and what might have happened to her overcomes the young boy. Marco thus decides to embark upon a journey to Argentina in the hope of being reunited with his mother. At first, Pietro is opposed to Marco`s plan, but moved by his son's enthusiasm, he eventually allows the boy to go. So begins Marco`s long journey of the heart. Marco encounters many people throughout his travels, and finds maturity and self-acceptance as a result of his experiences. (Source: Nippon Animation)