The anime series will adapt 20 stories from a number of Itou's manga for the first time, including Tomie, Souichi, and Kubitsuri Kikyuu (The Hanging Balloons).

In the ever-growing world of Duel Monsters, as duelists improve their skills and rise up the ranks, duels become increasingly complex. By adhering to strict rules, in addition to using and learning proven strategies, one can develop into a strong duelist. However, as a boy who loves inventions and discovering new possibilities, elementary school student Yuuga Oudou finds the current way of dueling predictable and rigid—in other words, boring. Thus, he aims to craft a new path in dueling with his exhilarating new invention: Rush Duels. His ambition soon catches the attention of Tatsuhisa Kamijou, a fellow elementary school student, who brings him to a mysterious place in an attempt to discover the potential of the new system. While Yuuga aims to implement Rush Duels as the new dueling standard and overthrow the conventions of the game, he opens the door to his ultimate goal—to make dueling exciting again.

Saenome are tasked with sealing spirits that possess objects and pose a threat to society. Known as tsukumogami, these spirits are generally non-violent, and saenome normally seal them after a simple verbal exchange. Traumatized by a previous deadly encounter with a malevolent spirit, Hyouma Kunato refuses to use peaceful methods and gets into physical confrontations with all tsukumogami that cross paths with him. Deeming this behavior unacceptable for a future clan leader, Hyouma's grandfather, Zouhei, proposes that he starts living with Botan Nagatsuki, a young woman whose family is composed of six tsukumogami—lest he be excommunicated. Determined to track down the spirit that took everything from him, Hyouma reluctantly accepts Zouhei's proposal. As unknown groups of evil spirits begin to jeopardize the balance between worlds, the young man must gain the trust of Botan and overcome his hatred for her mysterious family.

A spin-off chibi anime of .