The people of the kingdom look down on the young Prince Bojji, who can neither hear nor speak. They call him "The Useless Prince" while jeering at his supposed foolishness. However, while Bojji may not be physically strong, he is certainly not weak of heart. When a chance encounter with a shadow creature should have left him traumatized, it instead makes him believe that he has found a friend amidst those who only choose to notice his shortcomings. He starts meeting with Kage, the shadow, regularly, to the point where even the otherwise abrasive creature begins to warm up to him. Kage and Bojji's unlikely friendship lays the budding foundations of the prince's journey, one where he intends to conquer his fears and insecurities. Despite the constant ridicule he faces, Bojji resolves to fulfill his desire of becoming the best king he can be.

In this magical world, one is easily identified as having magical abilities by a distinctive mark on their face. Those unable to practice magic are swiftly exterminated to maintain the magical integrity of society. However, deep within a forest lies an anomaly in Mash Burnedead, who can be found pumping iron with one arm and lifting a cream puff with the other. This aloof boy with superhuman strength—but no magical abilities—leads a quiet life with his father, far removed from society. Mash's peace is soon disturbed when the authorities discover his lack of magical powers. They issue him an ultimatum: compete to become a "Divine Visionary," which would force everyone to accept him, or be persecuted forever. To protect his family, he enrolls in the prestigious Easton Magic Academy, which only the most elite and gifted students are allowed to attend. Now, Mash must overcome his shortcomings as a magicless being and surpass the other students—relying solely on his muscles.

Apprentice mage Chise Hatori is invited to enroll at the College, a prestigious learning institution for sorcerers, to examine and look for a way to remove the curses she bears. Despite her groom Elias Ainsworth's reluctance, Chise accepts the proposal, as she believes attending the school might help her minimize her self-sacrificing tendencies. From the get-go, Chise grabs the attention of her classmates and professors alike, who have never seen a mage in action before. However, there is a sinister plot brewing behind the College's back, and the young mage will have to determine who is friend or foe in order to put a stop to it.

Megumin is a young and passionate wizard from the Crimson Demon Village, a remote community of mages with red eyes and a flair for the dramatic. She has devoted her life to mastering explosion magic, a powerful but impractical spell that leaves her drained of mana and unable to move for the rest of the day. Regardless, she refuses to learn any other skills. Along with her childhood friend and self-proclaimed rival, Yunyun, Megumin enrolls in the Red Prison: a prestigious academy for Crimson Demon magic users. There, she learns more about the secrets and history of her clan, as well as the threats and challenges they must face. As she polishes her power at the Red Prison with the help of her loyal familiar Chomusuke and her adorable little sister Komekko, Megumin aims to become the greatest explosion wizard of all time!