Rei goes to an anime convention and ends up in a world created by the desires of anime fans. Rei doesn't know how to get back and the world starts to collapse because the convention is coming to a close.

Years ago, many magical "Artifacts" were stolen and scattered throughout the world. They fell into the hands of people who were not supposed to know of their existence, causing misfortune to those who abused their power. The Hoshisato family of magicians has special access to the Artifacts, and they take it upon themselves to return them to their rightful place. Despite her inexperience, Kana "Hatena" Hoshisato wishes to aid her parents Mamoru and Maeve in their quest, doing her best to improve. Meanwhile, her childhood friend Makoto Shiranui has come to their mansion to study magic under her father's tutelage as part of a promise they made years ago. Hatena is excited to see her friend again, only to be utterly disappointed when the person she thought to be a girl all these years turns out to be a boy, leading to a bitter reunion. Before long, Makoto comes to know of the Artifacts and the true identities of the magicians he admires. Unfazed, he continues to strive to fulfill his promises and stay true to why he learns magic—to ease the sadness of people around him and, most importantly, to become a person worthy of being Hatena's partner. [Written by MAL Rewrite]

By A.D. 2010, all men have died off quickly due to a dramatic change in the environment and an unknown contaminant. The population decreased to the lowest number ever seen...until only the women were left alive. They live huddled in small corners of a world mostly reclaimed by nature. There are those who accept their inevitable extinction and live a carefree life... There are those who try to continue on the race with the help of science... It is a society of constant conflict over their differences of principles and policies. The story takes place in the center of Tokyo. It is one of the places left for them. The conflict over the specimen of "ICE" and the chance it may provide to save humanity begins.

Those who receive the Revelation of Babel must overcome many battles and trials. By grasping the hand of their special partner, these "Hand Shakers" transport themselves to the realm of Ziggurat, an alternate dimension where time no longer exists. Each pair of Hand Shakers must battle it out for the right to meet with God, who will reward them by granting them a single wish. Tazuna Takatsuki, a high school student with a penchant for fixing things, is one of these Hand Shakers. After receiving a request for repairs from Professor Makihara of a nearby university, Tazuna stumbles upon Koyori Akutagawa, a bedridden girl that reminds him of his deceased sister Musubu. Remembering her dying wish to never let go of her hand, Tazuna grasps Koyori's hand and awakens his power as a Hand Shaker. However, Koyori's life is directly tied to her status as a Hand Shaker, meaning if Tazuna was to ever let go of her hand she would die. With meeting God being their only hope for saving her, the duo must find a way to make their unique powers mesh together, overcome the opposing Hand Shakers, and make their wish come true. [Written by MAL Rewrite]