Although traumatized by witnessing the murder of his parents by one of the Choushuu, Ichimura Tetsunosuke's thirst for revenge lead him to desire strength. At the age of 15, Tetsunosuke approached the Shinsengumi, wanting to become one of its members. However, Tetsunosuke lacked the skill, mind and will to emotionlessly cut down whoever threatened peace and the Shinsengumi. Even with the support of his brother Tatsunosuke and his newfound friends of the Shinsengumi, little did Tetsunosuke know the blood and pain he would have to face being part of this historical group.

Immortality is something many people would wish for. But would it be such a coveted ability if people knew they would be subject to countless attacks because of it? Such is the case for Rin Asougi, an immortal private investigator, because there is no shortage of people who want her dead. Over the centuries, she has met many grisly ends, but each time, she returns to life as if nothing had happened. In 1990, while looking for a lost cat, Rin runs into Kouki Maeno, a man who feels that his memories are wrong. Agreeing to help him, Rin discovers that Kouki is not what he seems, all the while drawing closer to her true enemy. This adversary knows Rin and her kind all too well, and if she dies by his hand, she may stay dead permanently. [Written by MAL Rewrite]

Due to his mother and sister, who both love professional wrestling, Kinjirou Sakamachi developed a resilient body that could take hard punches, aggressive kicks, and even deadly vehicle bumps, in order to survive their various grappling positions and locks. However, he also developed gynophobia, an abnormal fear of women. With just one touch from a girl, his nose bleeds uncontrollably, he sweats excessively, and in rare cases, faints abruptly. His life changes for the worse because of a fated meeting in the restroom. While trying to escape from a girl, he discovers that the most popular student in their school, Subaru Konoe—the butler of the headmaster’s daughter, Kanade Suzutsuki—is actually female! Surprised, Subaru violently assaults Kinjirou, dealing significant damage and knocking him unconscious. When he comes to, he meets Kanade. In exchange for his silence, she promises to help cure his phobia.

Kujo Jotaro is a normal, popular Japanese high-schooler, until he thinks that he is possessed by a spirit, and locks himself in prison. After seeing his grandfather, Joseph Joestar, and fighting Joseph's friend Muhammad Abdul, Jotaro learns that the "Spirit" is actually Star Platinum, his Stand, or fighting energy given a semi-solid form. Later, his mother gains a Stand, and becomes sick. Jotaro learns that it is because the vampire Dio Brando has been revived 100 years after his defeat to Jonathan Joestar, Jotaro's great-great-grandfather. Jotaro decides to join Joseph and Abdul in a trip to Egypt to defeat Dio once and for all.