Following the massive operation that led to the confinement of recent recruit Kafka Hibino, otherwise known as Kaijuu No. 8, the Defense Force has been puzzled by how to deal with him. Kafka is the first kaijuu to side with humans, and after careful consideration, he is eventually transferred to the Defense Force's First Division in the hope of adding his power to the strongest division, capable of handling any threat. However, some people are still doubtful about Kafka, and he must prove his worth in the next mission. Kafka and the First Division are soon dispatched when a massive horde of ant-like kaijuu begins wreaking havoc. Thanks to the combined strength of Kafka's friend Kikoru Shinomiya and their captain, Gen Narumi, the mission seems to progress as it should. However, when Kafka fails to transform into his kaijuu form, the dreadful Kaijuu No. 9 joins the battle with only one goal—to eliminate him and steal his power. Although the situation is looking grim, Kafka must overcome his most difficult trial yet with the others if he wants to keep pursuing his dream: fighting side by side with his childhood friend and Third Division captain, Mina Ashiro.

After waking from a long cryogenic sleep, high school student Akira Himegami finds himself in a world he no longer recognizes. The city lies in ruins from war, society is now governed by an organization called OWEL, and traditional marriage has been replaced by a new system known as "Elsie." As Akira struggles to comprehend this drastically changed future, a familiar figure appears before him—Yuugure, who bears a strong resemblance to his girlfriend Towasa. To his shock, Yuugure smiles gently and proposes: "Akira... please marry me." Confused by her sudden proposal, Akira agrees to travel with Yuugure, holding onto hope that somewhere in this world, the real Towasa is still alive. Along their journey, they encounter the evolving forms of love in this new era and reflect on what their bond truly means.

Attacker You! is the story of ambitious and energetic 13-year-old junior high schoolgirl You Hazuki (variously known as "Mila," "Jeanne" or "Juana" in Western dubbed versions of the anime), who moves to Tokyo from Osaka to live with her father Toshihiko, a cameraman recently returned from Peru, and attend school. You's mother is not in the picture, having left when You was very young. Also living with You and her father is her younger brother Sunny, who is very attached to his older sister and tends to follow her everywhere she goes, including to school and to her volleyball matches. You is also curious about Kyushi Tajima, the pretty blonde woman whom she sees covering volleyball games on television, and about why her father becomes very angry whenever You mentions her. You is passionate about volleyball and dreams of one day being a part of Japan's national women's volleyball team in the 1988 Seoul Olympics. She joins her school's girls' volleyball team and quickly becomes one of the top players, although her coach (who is also her homeroom teacher) is brutal and literally slaps his players around when they don't live up to his expectations. You begins a tumultuous friendship with former school volleyball champ and former arch-rival Nami Hayase (French name: "Peggy"), which comes to a head when the two girls join opposing professional teams. She also develops a crush on So Takiki, the captain of the Hikawa boys' volleyball team (known as "Shiro," "Serge" or "Sergio" in various Western versions), and puts as much effort into trying to win his heart as she does into her game.

The Daichis are a family in danger of tearing itself apart. Dissatisfied and money obsessed mom Seiko has served wimpy and otaku dad Mamoru with divorce papers. Daughter Nozomi who has always been saddled with all the housework, feels pained that everyone is using her. The youngest albeit most foul mouthed, Dai is forced to watch all this as everything is going to pieces. However when the Galaxy Federation recruits the Daichis to combat alien threats to the wellbeing of the Earth, it will be a chance for the family to save the world and maybe themselves.