In a near future, an illness called "Cagaster" made ​​its appearance. It turns humans into insects. The story begins 30 years after the onset of the illness, in 2125. It follows the adventures of Kidou, a boy who fights insects.

Shizuku Tsukishima is an energetic 14-year-old girl who enjoys reading and writing poetry in her free time. Glancing at the checkout cards of her books one evening, she notices that her library books are frequently checked out by a boy named Seiji Amasawa. Curiosity strikes Shizuku, and she decides to search for the boy who shares her love for literature.

Meeting a peculiar cat on the train, Shizuku follows the animal and is eventually led to a quaint antique shop, where she learns about a cat statuette known as "The Baron." Taking an interest in the shop, she surprisingly finds Seiji, and the two quickly befriend one another. Shizuku learns while acquainting herself with Seiji that he has a dream that he would like to fulfill, causing her dismay as she remains uncertain of her future and has yet to recognize her talents.

However, as her relationship with Seiji grows, Shizuku becomes determined to work toward a goal. Guided by the whispers of her heart and inspiration from The Baron, she resolves to carve out her own potential and dreams.

Each episode follows Fukuzou Moguro, a traveling salesman, and his current customer. Moguro deals in things that give his customers their heart's desire, and once his deals are made and their unhealthy desires are satisfied, Moguro's customers are often left with terrible repercussions, especially if they break the rules of his deals...

Takato and Guilmon go on vacation to Okinawa and meet a fellow tamer, Minami. Back in Japan, a popular computer pet suddenly becomes a virus, infecting all of the computers who have it. As the virus spreads, Takato tries to figure out why digimon are all attacking his new friend, and what her connection is to the virus.