Second season of . Kouichi Haimawari is a dull college student who aspires to be a hero but has given up on his dream. Although 80% of the world’s population has superhuman powers called Quirks, few are chosen to become heroes and protect people. Everything changes for Kouichi when he and Pop☆Step are saved by the vigilante Knuckleduster and get recruited to become vigilantes themselves!

It's 1863, the twilight of the shogunate, and Japan is on the cusp of monumental change. The streets of the nation's capital are soaked in blood as political upheaval and rising tensions between masterless, wandering ronin and government samurai set the stage for one of the most turbulent times in Japan's history. Young orphan Nio is no stranger to the harsh realities of the world, and yet he can't help but cling to his burning passion for justice and desire to change the world for the better. One day, he crosses paths with two men who will become central figures of the coming revolution: Hijikata Toshizo and Okita Souji, two of the founding members of a group of hated ronin known as the Miburo—who would later become known as the Shinsengumi. Inspired by the efforts of the so-called "Blues Wolves of Mibu," Nio decides to join the ranks to help carve a path to the world he wishes to see. But with new betrayals and reversals every day, will Nio be able to stay true to his conscience?

In the beginning, an "orb" is cast unto Earth. "It" can do two things: change into the form of the thing that stimulates "it"; and come back to life after death. "It" morphs from orb to rock, then to wolf, and finally to boy, but roams about like a newborn who knows nothing. As a boy, "it" becomes Fushi. Through encounters with human kindness, Fushi not only gains survival skills but grows as a "person". But his journey is darkened by the inexplicable and destructive enemy Nokker and cruel partings with the people he loves.

Let's walk and talk. Can you get up? The Gnosia lie. Pretending to be human, they'll get in close, trick and deceive, and then eradicate each person in the vicinity from the universe, one victim at a time. The crew of a drifting spaceship, facing off against a mysterious and deadly threat known as the "Gnosia" and having no idea who among them is really the enemy, formulate a desperate plan for survival. The most suspicious among them will be put into "cold sleep" one by one, in an effort to completely rid the ship of Gnosia. However, it is almost impossible to tell whether each person put into cold sleep was really Gnosia—or simply a poor, unfortunate scapegoat, sacrificed by the Gnosia for their own survival. Can the humans emerge victorious? Or is mankind doomed...?