In present times, Gods and Demons coexist together with Humans after the door between each of these worlds had opened. Tsuchimi Rin is a normal young high school student attending Verbena Academy, spending his days living peacefully with his childhood friend Kaede. Unexpectedly, one day the King of Gods, the King of Demons and their families move into be Rin's next door neighbors. Apparently the daughter of the Gods, Sia, and the daughter of the demons, Nerine, are both deeply in love with Rin after having met him in the past. Along with his playful friendship with upperclassmen Asa and his encounter with the silent but cute Primula, Rin has much on his hands dealing with the affections of each of these girls. Based on the eroge by Navel.

Major Land is a colorful world of music where instruments and notes come to life. During an annual concert event, Hummy, the cat songstress of Major Land, prepares to sing the "Melody of Happiness," capable of spreading happiness to worlds beyond. However, Mephisto, the king of Minor Land, interrupts the event and rewrites the score into the "Melody of Sorrow"—a dissonant composition that would instead cause despair when performed. In order to prevent this from happening, Hummy is tasked with finding the Precure, renowned warriors with an unmatched passion for music, and recreating the Melody of Happiness. Hummy arrives in Kanon Town, home of musically-inclined athlete Hibiki Houjou and studious baker Kanade Minamino. Engaging only in endless bickers, Hibiki and Kanade were formerly best friends and have since fallen out of touch. Their activities are stopped short by an unwelcome guest—the songstress of Minor Land, Siren. When Siren turns an important record into a gigantic monster, the girls' hearts resonate with the desire to protect what they hold dear and the two transform into the Suite Precure! As legendary warriors, Hibiki and Kanade will have to put their personal squabbles aside if they wish to protect the happiness of the world. [Written by MAL Rewrite]

After the 12 Gold Saints sacrifice their lives to destroy the Wailing Wall, The Bronze Saints enter the deepest realm of the Underworld, Elysion, where they face off aganist Hades's two most powerful servants: The Twin Gods, Hypnos and Thanatos, before they can reach Hades for the final battle.

Seiya and the rest of the Bronze and Gold Saints who have survived the Sanctuary battle have entered the world of the Dead. They are fighting to get to Hades and defeat him. (Source: ANN)