Three girls have been chosen by the great Shinju-sama to be heroes and fight against the destructive beings known as Vertexes—enemies that threaten the harmony and safety of the world. Unsure of when they would be called to duty, Sumi Washio, Sonoko Nogi, and Gin Minowa spent their time idly. However, with the sudden appearance of a Vertex, they realize they have no idea how to fight together as magical girls when they are nearly bested. They manage to defeat their enemy by sheer determination, but in the aftermath of the battle, the three decide to fix their teamwork issues and improve their combat capabilities. But as more enemies appear—and requiring even more power to defeat their nemeses—the girls may find themselves irreversibly changed by the use of their magic. What price will they have to pay to ensure victory, and is it one worth paying if humanity will be saved? [Written by MAL Rewrite]

Having fulfilled their destiny during the events of Yuuki Yuuna wa Yuusha de Aru, Sanshu Middle School's Hero Club—consisting of Yuuna Yuuki, Karin Miyoshi, and siblings Fuu and Itsuki Inubouzaki—is back in full swing, helping out those in need wherever they can. They have also gained a new member, a hero from the past named Sonoko Nogi. But eventually they notice that someone who should be among them, Mimori Tougou, is missing; any trace of her existence is completely gone, save for the girls' memories. With no leads on Tougou's whereabouts, the girls regain the ability to transform and begin the desperate search for their lost friend. But what they find is more shocking than any of them could ever have imagined, and the consequences of their actions begin to change life as they know it. [Written by MAL Rewrite]

Yumehara Nozomi, a regular student, finds a magical book called the Dream Collet in the library and meets Coco and Nuts, two creatures from the Palmier Kingdom. They plead with Nozomi to restore their world, which has been destroyed by an organization called the Nightmares, by completing the Dream Collet and finding the 55 Pinkies to make any wish come true. Meanwhile, the Nightmares are moving into the real world. Once Nozomi agrees to help, Coco and Nuts transform her into the magical girl Cure Dream and turn four fellow students into her Pretty Cure team. (Source: ANN)

A direct continuation of the former season, this series again follows the story of Nozomi Yumehara and her friends from Yes! Precure 5. The girls who had formerly lost their powers and bade farewell to their friends Coco and Nuts from Palmier Kingdom are resurrected as Pretty Cure by the mysterious woman Flora who also wants them to find her in a place called Cure Rosegarden. To go there, they need the magic Rose Pact and the powers of the four kings of countries surrounding Palmier. But a dark organization called Eternal is also striving to get to Cure Rosegarden by stealing the Rose Pact. Luckily, Precure get helped by new allies: the delivery-boy Syrup who can change into a giant bird and fly them anywhere they want and the mysterious and beautiful fighter Milky Rose stand alongside Pretty Cure to protect what is really valuable.