The second season of Kizuna no Allele. Miracle and her friends continue to chase their dreams as virtual artists!

When Isaku Senagaki was five years old, the death of her parents left her to be raised by her yakuza boss grandfather, Tasuke. Now preparing to enter high school, Isaku is determined to start fresh with an honest attempt at having a normal high school experience. All she wants is to be able to make friends and find love without being defined by her connection to the yakuza. But Isaku's dreams are thwarted when her overprotective caretaker, 26-year-old Keiya Utou, takes it upon himself to enroll in Isaku's school by bribing the school administration. While Isaku yearns for a reciprocated love, she is trapped in a one-sided infatuation with Keiya, who only sees her as the boss's granddaughter he helped raise. Her longing for a normal life becomes a constant battle, and breaking free from her heart's grip is far more challenging than it sounds, as Keiya's overprotectiveness and disregard for her boundaries make it almost impossible to move on.

The Yuzuki family, which consists of four brothers, lost their parents two years ago. Hayato, the eldest son, is a hard worker and the pillar of the family. Mikoto, the second son, is calm and collected, but he has a soft spot for his younger brother Minato, whom he adores and thinks is cute. Minato, the third son, is energetic and adores his brothers, but he is clumsy and awkward. Gakuto, the fourth son, is a studious and mature first-grader who is often referred to as a "wise man." The manga depicts the four brothers' daily lives as they navigate their family, school, and community.

Ryuuto Kashima is a gloomy high schooler. As part of a punishment game, he was forced to confess to Runa Shirakawa, a girl from the top of the school caste who was admired by everyone. They ended up going out for the unexpected reason of "Err, I'm free now so..." but Ryuuto ends up following and eavesdropping on Runa being confessed by a handsome soccer club member, and Runa bringing Ryuuto, whom she had just begun dating, to her own room as a matter of course. They have different friends and ways to have fun, and they are different in almost every way. Nonetheless, they begin to relate with each other after being surprised by their differences every day and accepting them.