Han Yuxi, a young woman who is insecure about her appearance, has tolerated criticism and abuse all her life. Devastated upon learning that her boyfriend has been cheating on her, she decides to take action and goes to a hospital to receive plastic surgery. There, she meets with plastic surgeon Ling Huantao, who wants to recreate the face of his vegetative wife who he is obsessed with. Huantao offers Yuxi the hope of living a better life, but a new face may not provide her with the happiness that she desperately desires.

Mushi-uta's story takes place in the near future. Ten years before the story's opening, strange insect-like creatures known as "Mushi" began appearing. The Mushi are able to consume peoples' dreams and thoughts in return for supernatural powers. At the end of episode one, protagonist Daisuke "Kakkou" Kusuriya encounters a young girl named Shiika Anmoto. The two, in time, become quite close. However, unbeknownst to Kakkou, Shiika is an escapee from a secret prison known as GARDEN where those posessed by the Mushi, known as the Mushitsuki are held. GARDEN's military force, the Special Environmental Conservation Executive Office, dispatches its finest killer to track down Shiika. However, they are faced with resistance from the Mushibane resistance organisation, led by the secretive "Ladybird."

Hiyori Hayama is an aspiring singer who moved to Tokyo to make her debut. She has always loved singing and hopes to stand on stage like her favorite artist. Unfortunately, the entertainment industry is not all fun and games, as she fails her auditions one after another and struggles to sell her songs. Finding herself still standing at the start line, Hiyori pursues her only opportunity to take the next step forward—partaking in Extreme Hearts. The popular event is a Hyper Sports tournament where participants compete in various sports using ability-enhancing gear for a chance to make their big break. Despite being athletic, however, Hiyori's lack of familiarity with Hyper Sports poses a problem for her. Fortunately, she befriends girls experienced in different sports, and they join the tournament alongside Hiyori, hoping to see her rise to the top. Now playing under Team RISE, Hiyori and her teammates learn about the unspoken rule of Extreme Hearts—all competitors must be entertainers or aspire to be one. For the members of Team RISE, facing the competition head-on is an inspiring endeavor that paves the way to discovering newfound interests and everlasting friendships.

A recap episode of the first season of Rinne no Lagrange.