In 2059, five decades after the Space War I conflict seen in the first Macross story. Macross Frontier, the 25th New Macross Class super-long-distance colonization fleet, is journeying through the galaxy to a new paradise to call home. However, it is locked in a state of war with a strange enemy called Vajra. Macross FB7 is the 30th anniversary work of the Macross franchise.

At the Personality Plant, robots are being built and slowly outfitted with the artificial memories of real people. Suzu is one such robot, being made to replace the young boy a family has lost. By chance, he meets Hotori, a young girl suffering from progressive memory loss. The two children become friends and attempt to define themselves in the light of their changing memories.

500 years ago in the Tensho Era of Japan, a man was born who defied the will of a demon; a man who had gods of good on his side; a man destined to battle evil....his name was Kabuto. Somehow, Kuroyasya Douki, the vile Black Night Demon, escaped his prison in hell and returned to the earthly plane to wreak vengeance on the family-line of Kabuto. None can escape his deadly magic and masterful skills with the blade; however, the gods of the North, West, East, and South band together to help Kabuto stand for Justice. With the questionable help of a diabolical talking sword that his own father forged, Kabuto may live another day to see his own sons born....