In 2035, an incident known as “The Burst” occurs at a Japanese research facility, giving birth to the rapidly expanding, consuming, and self-replicating "Matter." Snaking its way through the remains of dams and military facilities in the Kurobe Gorge, the hostile Matter is besieged by task forces trying to prevent it from reaching the ocean and mercenaries seeking the truth behind its existence. Aiko Tachibana lives under constant medical surveillance after being rescued from the Matter. She spends her days waiting out her recovery by making paper planes. Soon, her daily life at school is disturbed by the arrival of transfer student Yuuya Kanzaki, who proceeds to point out a number of inconsistencies regarding her body. Why is she never injured, and why does she suddenly no longer need her wheelchair? He claims that there is more to her existence than she has been led to believe, and that she alone holds the key to ending The Burst. With many factions now interested in Aiko, she and Yuuya must gather allies and embark on a dangerous pilgrimage into the heart of the infested gorge before the net can close around them. To escape the conspiracy moving against them, the pair must face off against the Matter—an enemy that flows like water. [Written by MAL Rewrite]

Nozomu Itoshiki is a high school teacher so pessimistic that even the smallest of misfortunes can send him into a pit of raging despair; some of these "catastrophes" even lead to suicide attempts. Sayonara Zetsubou Sensei is a satirical slice-of-life comedy set in the modern day, covering various aspects of Japanese life and culture through Nozomu and his interactions with his students: Kiri Komori, a recluse who refuses to leave the school; Abiru Kobushi, an enigma who frequently arrives to class with severe and mysterious injuries; the hyper-optimistic Kafuuka Fuura, Nozomu's polar opposite; and several other unusual girls, all of whom are just as eccentric as their teacher. [Written by MAL Rewrite]

Going into her first year of high school, Nanami Takahashi is filled with the hope of making many new friends. After meeting the shy Yuri Yamamoto, she hears about a popular boy in their class: Yano Motoharu. Yuri cares little for Yano because of his past relationship with her older sister Nana, and at first, Nanami doesn't like his attitude either. However, Nanami soon begins to warm up to Yano and takes a liking to him. The two spend more of their time together and eventually decide to start dating. But their love is not without challenges; Yano has trouble opening up to Nanami, since his first girlfriend, Nana, died in a car accident the year before, and she had been with one of her ex-boyfriends at the time. Finding themselves living in the shadow of Yano's relationship with Nana, Nanami and Yano struggle to keep their relationship afloat amid misunderstandings and heartache with the certainty of their love for each other. [Written by MAL Rewrite]

Yuuhi Katagiri is not your average girl – she's the treasured daughter of the Katagiri family. She's generally kept under strict supervision, but one day ends up walking home from school on her own. This proves to be instant trouble when a group of boys start harassing her. Junichi Nagase, who was on his way home from a convenience store, sees the troubled Yuuhi and comes to her rescue. One of the boys recognized Junichi as the famed "Geno Killer" and they dash off. Yuuhi thanks Junichi and when she asked for his name, he just waves and leaves. Of course, he regrets trying to act cool in front of the beautiful girl right away, wishing he asked her name. The following day, a transfer student joins Junichi's class – it's Yuuhi! She calls Junichi out as the "Geno Killer", the only name she remembers him by, and rumors about the two spread quickly. Matters are made worse when Junichi kisses Yuuhi due to a misunderstanding. And on top of all that, it turns out that Junichi is Yuuhi's fiancé! Yuuhi doesn't see Junichi as someone worthy. But, she could not go against her father's wishes. The only thing that Yuuhi can do is live with Junichi in the house he shares with his little sister Minato, and prove that Junichi is not worthy to be her husband. Will she succeed in proving his unworthiness, or will she fall in love on the way?