Taito has been really sleepy lately, and keeps dreaming of a female vampire who says she has given him her "poison." Sometimes he even thinks he hears her voice when he's awake. But after surviving an accident that should have killed him, Taito's world changes drastically and he realizes that his dreams are more real than he thought.

Season 5 of Natsume Yuujinchou.

Some time ago, the influential and powerful Toue Inc. bought the island of Midorijima, Japan, with the plans of building Platinum Jail—a luxurious utopian facility. Those who are lucky enough to call it home are the wealthiest citizens in the world. The original residents of the island, however, were forced to relocate to the Old Residential District; and after the completion of Platinum Jail, they were completely abandoned. "Rib" and "Rhyme" are the most common games played on the island. Rib is an old school game in which gangs engage in turf wars against each other, while Rhyme is a technologically advanced game wherein participants fight in a virtual reality. To be able to play Rhyme, you must have an "All-Mate" (an AI that typically looks like a pet), and the match must be mediated by an "Usui." Aoba Seragaki has no interest in playing either game; he prefers to live a peaceful life with his grandmother and All-Mate, Ren. However, after getting forcefully dragged into a dangerous Rhyme match and hearing rumors about disappearing Rib players, all of Aoba's hopes of living a normal life are completely abolished.

Within Cardia Beckford's hazy memories, she can recall her father Isaac and the home where she lives alone, feared as a monster by the townsfolk—for in her body, she carries a deadly substance. Embedded in her chest by her father, the eternally beating heart—also known as Horologium—has the capability to produce infinite power. However, it also makes her skin destroy anything it touches. Many in London seek the Horologium, including the terrorist organization Twilight, with whom Isaac is rumored to have close ties. To obtain the Horologium's power, the British military forces Cardia to leave her home as their prisoner. But on the road, she is whisked away by the gentleman thief Arsène Lupin, who says he will steal her heart. Joining Lupin and his companions, Cardia begins a journey to discover the truth behind Isaac's connection with Twilight, her missing memories, and the Horologium within her chest. [Written by MAL Rewrite]