The story will follow four girls who seek to use their songs to heal and soothe the people of their world. The tagline reads, "Kindhearted, powerful songs heal the world. These are beautiful miracles sung by humanity."

Two years after the Summit War, Monkey D. Luffy plans to reunite with the Straw Hat Pirates in the Sabaody Archipelago. However, the Marines obstruct Luffy's path with overwhelming force. Meanwhile, the Straw Hats must also foil the schemes of a group of impersonators acting in their likenesses. With two years of intensive training with allies old and new, Luffy regroups with his friends aboard the Thousand Sunny to set sail for the New World. As the Straw Hat Crew departs for Fish-Man Island, new threats creep up from the abyss. But more determined than ever to become the King of the Pirates, Luffy is prepared to defeat any enemy that may stand between him and his dream.

Crimson Denizens and Rinne, beings from a parallel world, seek to devour humans' precious existences. To restore the delicate balance of the world, Flame Hazes hunt these entities down. Yet such things are unknown to Yuuji Sakai, who starts his day like any other and heads to school. His day, however, takes a turn for the extraordinary when he witnesses everyone around him freeze in place and is left the only one able to move. Immediately, a Rinne begins devouring the souls of those around him, but as the creature sets its sights on Yuuji, a katana-wielding Flame Haze with blazing red hair saves him. After his protector fixes the damage done, she explains why Yuuji was able to move: he has become a Torch, a remnant of a dead human being that will eventually fade from memory. Furthermore, he is also a Mystes, a Torch that houses an unknown treasure. Before his flame burns out completely, a Crimson Denizen will try to seize the treasure he holds, so the fiery hunter decides to watch over him. As Yuuji comes to terms with being dead, he resolves to live his life the best he can with the time he has remaining. [Written by MAL Rewrite]

At last, the Sanzou Party has arrived in India. In this foreign land, where the anomaly's influence runs rampant, their battles only heighten in their violence. And also awaiting them is their tragic fate from 500 years ago— What will they find at the end of their long and treacherous journey?