Tooru Kirishima's notoriety is spread far and wide in the underworld. He is most commonly known as "The Demon of Sakuragi"—a man who is not afraid to resort to violence if deemed necessary. After almost jeopardizing a peace treaty, his boss tasks him with the most difficult job he has ever had: taking care of seven-year-old Yaeka Sakuragi—the boss' precious daughter—so that Tooru understands what it means to be responsible for another life. At first, the two do not seem to meet eye to eye, as Tooru has no clue on how to communicate with Yaeka, and the young girl is not used to expressing her emotions. However, as time goes on, they come to understand each other despite their differences. The fearsome right-hand man of a yakuza boss and the child he must protect are about to learn that family is not always bound by blood.

Years after an ancient evil was salvaged from the depths of the sea, Joutarou Kuujou sits peacefully within a Japanese jail cell. He's committed no crime yet demands he not be released, believing he's been possessed by an evil spirit capable of harming those around him. Concerned for her son, Holly Kuujou asks her father, Joseph Joestar, to convince Joutarou to leave the prison. Joseph informs his grandson that the "evil spirit" is in fact something called a "Stand," the physical manifestation of one's fighting spirit which can adopt a variety of deadly forms. After a fiery brawl with Joseph's friend Mohammed Avdol, Joutarou is forced out of his cell and begins learning how to control the power of his Stand. However, when a Stand awakens within Holly and threatens to consume her in 50 days, Joutarou, his grandfather, and their allies must seek out and destroy the immortal vampire responsible for her condition. They must travel halfway across the world to Cairo, Egypt and along the way, do battle with ferocious Stand users set on thwarting them. If Joutarou and his allies fail in their mission, humanity is destined for a grim fate.

After waking from a long cryogenic sleep, high school student Akira Himegami finds himself in a world he no longer recognizes. The city lies in ruins from war, society is now governed by an organization called OWEL, and traditional marriage has been replaced by a new system known as "Elsie." As Akira struggles to comprehend this drastically changed future, a familiar figure appears before him—Yuugure, who bears a strong resemblance to his girlfriend Towasa. To his shock, Yuugure smiles gently and proposes: "Akira... please marry me." Confused by her sudden proposal, Akira agrees to travel with Yuugure, holding onto hope that somewhere in this world, the real Towasa is still alive. Along their journey, they encounter the evolving forms of love in this new era and reflect on what their bond truly means.

With a cartload of fur pelts in tow, traveling merchant Kraft Lawrence stops by the village of Pasloe. According to local folklore, centuries ago, one of the villagers made a promise with the wolf deity Holo, who swore to bless Pasloe with bountiful harvests of wheat. Yet, as time passed, such stories became little more than relics of the past. After quickly finishing his business in the village, Lawrence sets out to his next destination. His journey, however, takes an unexpected turn when he discovers a nude, animal-eared girl sleeping among his pelts. Even more surprisingly, the youthful-looking woman claims to be Holo—the wolf of legend. Holo wishes to return to her hometown in the north, and though their first encounter is rocky, she convinces Lawrence to accompany her on her travels. In return, she vows to earn her keep, using her quick wits and lifetime of experience to help her newfound companion in his dealings. As they continue their journey, Lawrence and Holo take advantage of whatever economic opportunities they come across, often landing in situations that put both their business skills and their relationship to the test.