The anime follows a group of friends Giulia, Maria, Enrico, Lucio and Angelon during the disaster as they team up with a Japanese journalist Shiro Ando, and begin their own investigation of what's occurring (during the week long period of exposure when the ICMESA refused to notify citizens of the poison). As many animals are dying and people are getting sick. The children and Shiro discover deadly dioxin was released and inform Enrico's father, the town mayor, who evacuates all the citizens. Shiro continues investigating more and learns of the negligence of La Roche, a company who controls ICMESA. La Roche knew they were in violating of existing safety laws/protocols and destroyed evidence of their crimes. The children attend a press conference to ruin La Roche's reputation as the destroyed proof might not be enough in a court of law to punish them. Giulia's pregnant sister, who opted to not abort, gave birth to a healthy girl. The happiness is short lived, as the baby prematurely dies from dioxin poisoning.

August 1945. In a converted theological seminary on the outskirts of Nagasaki, a young doctor works to help his patients, as unsettling news comes of a new weapon used by the Americans on the city of Hiroshima. When the second nuclear weapon is dropped on Nagasaki, the hospital staff must work to save lives in the midst of the concentric circles of death that their city has become.

Based on the literary work of Shikibu Murasaki, The Tale of Genji is a story of the Emperor`s second son born by a courtier. Made a commoner, he served as a retainer to the court.

When Ryu returns to pay homage to his deceased mentor, Gouken, he is tormented by disturbing memories of his master's killer. In a quest to become a true martial arts master, Ryu sets out to hone his street fighting skills and to deliver himself from the haunting legacy of the Dark Hadou. But the ultimate test of his new power can only be accomplished through one last fateful confrontation with his arch-nemesis, Gouki (Akuma).