Jesus Christ and Gautama Buddha, the founders of Christianity and Buddhism, are living together as roommates in a Tokyo apartment while taking a vacation on Earth. The comedy often involves jokes about Christianity, Buddhism, and all things related, as well as the main characters' attempts to hide their identities and understand modern society in Japan.

Valentine's Day is approaching; Hosaka is still trying to express his love to Haruka by cooking, cross-dressing Mako-chan fears to be found out, Kana-"sensei" teaches the other girls how to "win" Valentine's Day, and Fujioka is desperately trying to receive Kana's chocolate.

Ryouhei Arisu is a high school student with no ambitions and just wants to escape from what he feels is a meaningless reality. One night when he is with his two friends Daikichi Karube and Chouta Segawa, they see an abnormally large firework shoot into the sky, an event which signals a permanent change in their lives. Blinded by the incredibly bright explosion, the three find themselves transported to what is known as the Borderland. The only inhabitants of this world are participants of a deadly game where specific tasks must be accomplished if they wish to survive. As the three begin playing to determine how they can get back home, Ryouhei finds himself feeling alive for the very first time in his life. [Written by MAL Rewrite]

Sora Naegino has finally consolidated herself as Kaleido Stage's greatest star ever, and a new star starts to shine as Rosetta Passel is selected to participate in the next attraction in a main role. But when things start to go wrong in the rehearsals, Rosetta starts to question her abillity to take the role, as her own capacity to remain in Kaleido Stage. Meanwhile, Fool also struggles with his demons from the past.