Sorao is an ordinary student who lives an ordinary everyday life of a typical kid, accidentally makes friends with two aliens stranded here on Earth. His life changes as he decides to help them find a way to get home. When they do reach the aliens' homeworld, Sorao along with Miki, discovered a blood feud between two different tribes. Things gone awry as the tribes' representatives try to out do one another in search of the missing treasure of the past with the help of an uncovered clue. (Source: ANN)

As with both the Advanced Generation and Diamond & Pearl series before it, the Best Wishes! series begins with only Satoshi, headed off to the Isshu region, located far away from Kanto, Johto, Houen, and Sinnoh, with his Pikachu. After he meets up with the new trainer and rival Shooty and the region's Professor Araragi, he gains traveling companions in Iris, a girl from a town known for its Dragon Pokémon, and Dent, Pokémon Connoisseur and the Grass Pokémon specialist of the three Sanyou City Gym Leaders.

Satoshi, Iris & Dent continue their travels through the Isshu region. After successfully winning his 8th Gym Badge against Homika in Tachiwaki City, Shirona invites everyone to stay at her villa in East Isshu, where old friend Hikari is also staying, and participate in the Pokemon World Tournament Junior Cup before Satoshi participates in the Unova League. Team Rocket, meanwhile, initiate their final plan for the Isshu region-what is their purpose in their desire for the legendary Pokémon Meloetta?

In this new series, Satoshi, Pikachu and friends start a new journey towards the "White Ruins." There, they meet the young "N", who can hear the voices from Pokémon's hearts... The door of truth leading to an Utopia for Pokémon and humans now lies open! (Source: AniDB)