After an awe-inspiring battle with Ichibei Hyousube—leader of the Soul Society's Royal Guard—the powerful Yhwach moves into the final stage of his master plan. He aims to slay the Soul King, the being whose very existence maintains the status quo of three worlds: Hueco Mundo, the Soul Society, and the realm of humans that Ichigo Kurosaki and his closest friends hail from. Conquering his own bout with the remainder of the Royal Guard, Uryuu Ishida joins Yhwach in his efforts to create a new world in his image. With a flood of resolution and newfound power, Ichigo rushes to stop Yhwach from accomplishing his ultimate goal and save the countless lives within the three existing realms. But Ichigo has a complicated lineage, one that leaves him susceptible to Yhwach's sinister influence. Meanwhile, in a final desperate gambit, Jirou Sakuranosuke Shunsui Kyouraku, the newly promoted head captain of the Soul Society's combat corps, enlists the help of an old enemy whose immense power may turn the tide of battle.

The next phase of the controversial Blue Lock project is underway with the candidate pool being dwindled down to just 35. Out of the remaining strikers, only a select few will be chosen to play in an upcoming exhibition game against the current U-20 Japanese soccer team. Playing in this match comes with a caveat: winning will grant the players the right to represent the nation as the new U-20 team, but losing will bring an end to Blue Lock in its entirety. Among the ones left in the running is Yoichi Isagi, who is coming to terms with his own abilities. To further complicate matters, the six best players in the pool have already been named to the starting lineup and the remaining 29 will have to duke it out to claim a coveted spot. Each candidate must select a top six pairing to team up with for the selection to prove their competence. But if this mishmash of strikers wants to overthrow the current U-20 team, they will need to find a way to combine their playstyles effectively.

After the intense quarterfinals, the U-17 World Cup competition has been whittled down to four formidable teams. Standing between Team Japan's quest for international glory is the nine-time tournament champion, Germany, and their star-studded team, pro player Jurgen Borisovich Volk at its helm. With both the momentum and the crowd's favor on the side of their opponents, Japan faces an uphill battle. Determined to avenge an earlier loss, Japan sends seven of their best—including team captain Houou Byoudouin—to challenge the German national team. But trying to reach the finals for the first time in Japan's tennis history may cause even these fearless players to crumble under mounting waves of pressure as they venture into uncharted territories.

The chaotic aftermath of a confrontation between Jinka Yamato and Yazen results in the power dynamics between the magically gifted katawara and humans being turned upside down. As the news of the downfall of dangaishu—the katawara-hunting monks led by Yazen—spreads across the country, rogue groups of katawara start to form, worsening the already-fragile relationship between them and humanity. Having lost faith in his abilities, Shinsuke Hyoudou now spends his time heavily drinking in the company of Senya, a former enemy of his who controls one thousand katawara within his body. Senya indirectly causes the death of the father of Tsukiko, his newfound friend, after a surprise attack of a local god gone berserk. Despite the circumstances, Tsukiko holds no grudge against Senya and is determined to become Shinsuke's disciple no matter what. Although Shinsuke refuses to become Tsukiko's sword instructor, he reluctantly agrees to let her travel with him and Senya. While the unlikely trio heads towards their next destination, Tama Youko continues her journey to find the trail of Jinka, the nine-tailed fox who has the power to destroy the world.