It is the year 2201. The Yamato has returned from the devastating battle with Emperor Zordar and the Comet Empire. Sanada, Aihara, and Shima are released from the hospital, and go to pay their respects to the fallen crew members at Okita's memorial. They meet Tokugawa's son Tasuke, who says that he will be joining the crew once he graduates from cadet school. The next day at his graduation, he ends up capsizing a boat full of new cadets because they are all too busy staring at the Yamato to watch where they are going. After some problems during launch due to the new engine crew hitting the wrong switches and stalling the ship, the Yamato departs on what should be a simple training mission.

The half-divine King of Uruk, Gilgamesh, was considered but a paltry legend... until his majestic tomb was discovered in the Middle East. This imperial crypt drew scientists from across the globe to the land, and with that came recognition of their fame. In a joint effort, they built Heaven's Gate in pursuit of advancing human knowledge. One day, a group of terrorists driven by greed attack Heaven's Gate, causing an explosion within the facility for archaeological excavation. The resulting phenomenon had much more impact than anyone could have imagined. More specifically, it triggered the birth of supernatural beings. In the midst of this mess, two siblings by the names of Kiyoko and Tatsuya encounter mysterious men with supernatural powers who, despite the scientific crisis around them, claim the ability to restore good to the world. Nevertheless, these seemingly heroic and all-powerful creatures act under the rule of factions. Are they here to save the world, or destroy it?

A deadly virus known as "Algernon" has attacked humanity with vicious meaning. At the forefront of the battle is the mystifying Akamatsu Industries—disguised as a heavy machine factory in Tokyo, this undercover organization uses neural enhanced weapons known as NeuroNoids to battle Algernon. Also helping with their secret efforts is the mysterious mutant who is only known as "Betterman." (Source: ANN)

Twintails: the glory of all mankind—or at least that is what first-year high school student Souji Mitsuka believes. At school, Souji spends most of his time daydreaming and rating girls' twintails, even going as far as creating a club dedicated to the hairstyle. His obsession does not go unnoticed, however; when monsters from outer space attack Earth and claim the world's twintails for themselves, a strange woman named Twoearle enlists Souji to fight back using twintails of his own! By transforming into the twin-tailed warrior Tail Red, Souji combats the vicious alien organization known as Ultimegil, whose main goal is to colonize Earth and steal everyone's spiritual energy, or "attribute power." Alongside fellow twin-tailed fighters Aika Tsube and Erina Shindou, Souji must find a way to defeat the invading army and defend the twintails he holds so dear. [Written by MAL Rewrite]