After her parents are killed by bandits, young Sarasa Feed is sent to an orphanage where she learns about the prestigious world of alchemy. Determined to follow in her late parents' footsteps and become an independent business owner, she enrolls at the Royal Alchemist Academy to train and get certified as an official alchemist. Five years later, Sarasa graduates from the institution and nearly achieves her dream before realizing that she lacks the funds to do so. Left with little choice, she makes do with a low-priced storefront in a town situated far away from the bustling capital. Despite the threat of treacherous terrain and dangerous monsters in the remote countryside, Sarasa begins her exciting new life as an alchemist.

High school girl duo Popuko and Pipimi are back and more unhinged than ever after their initial efforts to create a full-fledged anime production were met with a great reception. With no regard for their audience, they continue to live their reckless everyday lives consisting of comedy skits and parodies of epic proportions. No one is immune to the effects of their antics—including hapless live actor Shouta Aoi, who is on the run and stuck trying to be a hero in the wrong series.

Al Wayne's greatest goal is to become the best farmer he can be. With utmost effort, he reaches the apex of his farming skills and earns the title of a first-rate cultivator. Due to this achievement, Al gains a substantial upgrade to his stats which now eclipse even the strength of legendary heroes of old. Soon after discovering his potential, the royal family enlists his help against the rising number of disasters that coincidentally began right as his true power was awakened. Although reluctant, Al concedes that in order to protect his precious fields, he must do his best to keep all threats at bay.

Koujirou moves to Tokyo from Japan's northernmost island of Hokkaido and insists on bringing his favorite horse, Hikarikin, with him. The alien king Rel arrives from planet Wedelun and gives him a belt that will allow him to transform into a Miracle Hero and to protect the world from alien menaces. He is more interested, however, in impressing the pretty Yuka, though his rival, Michinari, wants her for himself.