The year is 2046. Detective Ross Sylibus is transferred to Mars when a country singer on her flight is murdered. Making matters more complicated is that the singer is a "Third"—a robot that looks and feels like a human. Sylibus is partnered with Armitage—a beautiful female cop with a bad attitude. As they investigate the murder of the singer and other women on Mars, they uncover a conspiracy that can have them both killed by the Martian government.

Set in a different series of events, this story does not follow the previous Appleseed movie canon (despite being directed by the same director of the previous movies); it is an alternate story to their beginnings. Briareos is already a cyborg and did not become separated from Deunan to be later reunited in Olympus to join ESWAT.

Appleseed Alpha depicts the early days of Deunan Knute and Briareos in the 22nd century, as they embark on a journey throughout dystopic ruins of New York in search of the city of Olympus. They are hired by Two Horns, the warlord of the ruined city, to eliminate bipedal combat machines. During the fight, they encounter Iris and Olson, both on a mission. Deunan and Briareos befriend them and decide to join their mission.

Iris is tasked with preventing the malevolent cyborg Talos from capturing a secret weapon humans were building. Talos uses Iris to activate the gigantic war machine.

(Source: Wikipedia)

Home to countless street acts and performances, Veludo Way attracts those interested in watching professional actors. After receiving a mysterious letter, Izumi Tachibana arrives at the venue where her father directed a once-popular theater group, Mankai Company, but learns that the building is about to be repurposed due to excessive debt. At the last minute, she convinces the debt collector to give the ensemble one more chance. He is willing to accept but on three conditions: their debut show must be successfully produced by the following month, the four all-male sub-troupes must be reinstated, and the debt must be paid off within a year. To top it off, Izumi herself must become the director. With no time to lose, Izumi quickly gathers five people for the Spring Troupe: Sakuya Sakuma, an enthusiastic high school student; Masumi Usui, a boy infatuated with Izumi; Tsuzuru Minagi, an aspiring playwright; Itaru Chigasaki, a mature office worker; and Citron, a friendly foreigner. Though they have little or no experience in acting, it's up to Izumi to train and prepare them for a performance that will restore Mankai Company to its former glory.

Souzou Haran was a brilliant scientist that was conducting research on Mars. He created a form of cyborg life with the ability to think for itself. These cyborgs, dubbed the Meganoids, soon ran out of control and killed Dr. Haran along with his whole family, save his youngest son, the 16-year-old Banjou Haran. Banjou escapes from Mars on a rocket with a solar-powered super robot called Daitarn 3, which was built with the special metals of Mars. Now eighteen years old and living on Earth in a luxurious mansion, Banjou fights against the Meganoids with the aid of his faithful butler Garrison and his two gorgeous companions Reika and Beauty. Together they must stop the evil Meganoids which aspire to turn all humans into cyborgs and thus "improve" the human race. (Source: AniDB)