Shintarou Tokumitsu leads an ordinary high school life while living in a studio apartment just for himself. This changes drastically one morning after he finds something strange on his balcony—an angel from Heaven. The innocent and kind girl named Towa was sent to Earth by God to learn more about humans and their way of interacting. It does not take long for her to get attached to Shintarou, who eventually allows her to live with him. However, the small apartment provides little personal space and privacy, and hiding Towa's real identity from the public proves difficult. As he learns to navigate his new life with Towa, Shintarou's encounters with other girls may only complicate the circumstances.

Homeless and fresh out of employment, Mito Yamamoto faces familiar loneliness and despair. Luck is simply not on Mito's side; when he stumbles upon a cafe and cuts his hand, a strange server named Ruka Saotome licks the blood from his wound and even dramatically retches at its apparent disgusting taste. Offended and dispirited, Mito runs off to a bridge, hoping to put an end to his misery. But when Mito accidentally slips, he is miraculously saved by Ruka, who reveals he is a vampire. Unable to drink blood from just any woman for mysterious reasons, Ruka proposes that Mito become his thrall—a vampire's human servant and primary source of food. In this deal, Ruka will shower Mito with love to sweeten his blood, and Mito will gain a warm place to call home. However, there is an issue: Mito is a girl! Concealing her long, flowing hair and feminine body, Mito readily takes this chance and enrolls in the Hijirigaoka Boys' High School while working part-time at the cafe with Ruka. But the more Mito's bond with Ruka deepens, the more she struggles to hide her secret.

Hoping for a fresh start, househusband Masaki Fujiyoshi, his spouse Hiromu, and their toddler son, Hikari, move to a new neighborhood. The couple's union was frowned upon by many due to Masaki's status as an omega—a secondary gender that allows an individual to give birth. Even for an alpha—seen as the superior secondary gender—such as Hiromu, discrimination seems to be commonplace and a hindrance to a life of domestic bliss. Fortunately, the new family is not alone. Little Hikari becomes attached to Yuuki Hirai, the Fujiyoshis' lonely college student neighbor. Despite his initial reluctance, Yuuki ends up befriending the infant. Moreover, the family can also confide in Hiromu's childhood friend and coworker Tomohiro "Matsu" Matsuo. Although everything is going well for the young couple and their child, a sudden presence from the past might pose a problem for the peaceful life they dream of.

Everyone yearns to find their true purpose in life. This is also true for Nina Iseri, a 17-year-old girl looking to enroll in a good university, but the world always seems to work against her. On her very first day in Tokyo, she gets lost, ignored, and locked out of her new apartment. However, an unexpected opportunity arises when Nina meets Momoka Kawaragi, one of her favorite guitarists. After Nina joins Momoka for a street performance, Momoka decides they should start a band together. While Nina initially hesitates, her determination grows as they start acquiring more bandmates—the beautiful drummer Subaru Awa, the aloof keyboardist Tomo Ebizuka, and the intelligent bassist Rupa. The five girls face challenges both in the music industry and within themselves, but their shared passion for music never lets them give up on their dreams.