Following the successful end of the Fourth Shinobi World War, Konohagakure has been enjoying a period of peace, prosperity, and extraordinary technological advancement. This is all due to the efforts of the Allied Shinobi Forces and the village's Seventh Hokage, Naruto Uzumaki. Now resembling a modern metropolis, Konohagakure has changed, particularly the life of a shinobi. Under the watchful eye of Naruto and his old comrades, a new generation of shinobi has stepped up to learn the ways of the ninja. Boruto Uzumaki is often the center of attention as the son of the Seventh Hokage. Despite having inherited Naruto's boisterous and stubborn demeanor, Boruto is considered a prodigy and is able to unleash his potential with the help of supportive friends and family. Unfortunately, this has only worsened his arrogance and his desire to surpass Naruto which, along with his father's busy lifestyle, has strained their relationship. However, a sinister force brewing within the village may threaten Boruto's carefree life. New friends and familiar faces join Boruto as a new story begins in Boruto: Naruto Next Generations.

In the first test of a revolutionary personal battle-suit, the MADOX-01, Ace female test-pilot Elle Kusomoto smashes an attacking tank force and humiliates Lt. Kilgore, Japan's most-macho tank-jockey, in the process. Kilgore swears he'll get even, and he gets his chance when the prototype MADOX literally falls off the back of a truck in the middle of Tokyo. Meanwhile, the MADOX, which fell off the back of one truck, off a bridge, and into the back of another truck, has found its way into the hands of college student Koji Sujimoto. Intruiged by the MADOX, Koji makes the big mistake of fooling with it without reading the manual first, and soon finds himself locked in the suit and zooming around downtown Tokyo.

Nuclear testing has resulted in the abrupt evolution of the Fumoon, a tiny but highly intelligent humanoid race on a small island, who are detected by Dr. Yamadano. Except for a few witnesses including the detective Shinsaku Ban, and the young men Rock and Kenichi and Kenichi’s sister Pichi (Pinoko), no one believes him. The Fumoon are kidnapping animals from around the world to bring with them as they use their space ships to evacuate the earth, because they know Earth is shortly to be destroyed by an enveloping cloud of black gas created by a stellar explosion. The Fumoon intend to abandon mankind, but one Fumoon, Rokoko, who becomes good friends with Kenichi, tries to help Dr. Yamadano and the others to develop a space ship to allow a few humans to escape, with the help of Dr. Ochanomizu and Dr. Frankenstein.

Azalea has been residing on the Colony-Planet of Dinahl, and she can't recall anything about herself until she hears a voice calling her name. Then there is another voice summoning her to go to a park on top of a skyscraper. Once she arrives there, she meets up with other people who also have no recollection of who they are or what they were doing before arriving at this destination as instructed by the voice. All the people assembled there possess superhuman powers, such as Eno's psychic power, Umoth's x-ray vision, Neia's teleportation powers, Azalea's telepathy, and Locke's electrical wizardry. Who has summoned them, and what will the five super-psychics confront?