Outside the magical barriers lies a world overrun by fiery beasts known as Flame Demons, and the only ones who can protect humanity are the Fire Hunters. In the dark woods where the beasts roam is where Touko, a young villager, is rescued from attack by one of these skilled trackers, Koushi. But their meeting was no accident, and a new destiny begins.

The year is 2222. It has been years since Tears of the New Moon, a mysterious rain, poured and wiped out almost the entire human race. The poisonous rain gave birth to deformed creatures devouring humans, and humanity fled from the danger. As means for survival, the humans then build an underground haven; Amasia. In this newly built dystopian city, in a pursuit of maintaining their existence, they run into an Artificial Intelligence named Magus. Not knowing how things will work between them, the story of how Humans and AI coinciding and trying to find their truths begin.

Gekkan Mousou Kagaku is set in Most City in an unknown country in a small publishing house that prints a monthly magazine about the most outlandish of things. Everything changes when the staff of the magazine, editor-in-chief Tarou, his assistant Jirou and dog Saburou, meet with scientist Gorou Satou...