On the planet Earthdash, its inhabitants gaze on its moon and the technologically advanced lunar city of Mooneyes with awe. Dan JD, a boy living in Rollingtown on Earthdash's surface, gets caught up in Bigfoot Basketball—a fast-paced sport played with giant Bigfoot robots.

Natural disasters have devastated planet Zi, killing off almost all life. A thousand years later humans have gradually re-established civilization, salvaging ancient Zoids through diving and mining efforts. In a village whose most previous item is a giant sword which they worship as a holy symbol. A teenage boy discovers an ancient Liger-type Zoid while on a deep water salvage operation. Suddenly the village is attacked by skeletal Bio-Zoids intent on stealing a powerful generator located in the village. Our teenage hero awakens the Liger and discovers that the town`s sacred sword is the Liger`s weapon, together they fight off the mysterious Bio-Zoids. At least for now...

In the 1960s, a gifted young medical student tries to make a name for himself. Kuroo Hazama is a reserved young man with unusual black-and-white hair, a body covered with scars, and a dark past. Despite only being a medical student, his surgical brilliance starts to attract attention after he completes a seemingly impossible operation. Together with the spirited and honest intern Maiko Okamoto and Yabu, a close friend with a troubled life, Hazama devotes himself to the world of medicine. However, his path to becoming a respectable surgeon is a difficult one as student riots, war, and corruption are consuming Japan. Hazama quickly finds himself caught up in a series of nefarious circumstances that challenge his integrity as a person and his path towards becoming a surgeon. Young Black Jack chronicles the story of a man capable of performing unthinkable feats of medicine, and the journey that leads him to become the legend known as Black Jack. [Written by MAL Rewrite]

In a world where dead people turn into books and are stored in the Bantorra Library where anyone who reads a book can learn their past, Bantorra Library is maintained by Armed Librarians who wield psychic powers and their enemy is a religious society known as Sindeki Kyoudan.