Venturing into the wilderness, the skeptical Ryouta Murakami and the ambitious Kuroneko were on a quest to prove the existence of extraterrestrial life when a tragic accident occurred, reaping Kuroneko of her life and leaving Ryouta in a critically injured state. Ten years have passed since the disaster, and Ryouta is now living a normal life in high school. He vows to prove that aliens are real in honor of his late friend. A transfer student named Neko Kuroha unexpectedly arrives one day, bearing a striking resemblance to the late Kuroneko—even sharing a similar name. Most mysteriously, she seems to possess supernatural powers. As Ryouta takes more interest in Neko, he is drawn into a deadly world where dangerous scientists hunt magic-wielding witches that have escaped from their secret research laboratory. Neko is one of these escapees, but there are many others who are in similar situations, and it's up to Ryouta to protect them from their would-be captors.

Randou Rino is a young girl with a head full of air and a talking puppet on her hand. She is accepted into the illustrious Gokujou all-girl's school, and is summarily, almost curiously, accepted as part of the even more illustrious Gokujou Student Council, who has more power and business ventures than most large businesses. Now a part of the student council, she befriends the talented members of the Gokujou Student Council, leaving one to wonder how a girl with seemingly no talents or redeeming qualities would get chosen for such a group. (Source: ANN)

Leona Ozaki joins Newport City's infamous Tank Police division. With aid of Al and her newly built mini-tank, Bonaparte, she wages war on Buaku and his cohorts, the Puma Sisters.

Modern Germany is plagued by an outbreak of "Amalgams." Existing solely to wreak havoc, these cybernetic entities spawn from rotting flesh and can fuse with technology to gain new abilities. With society left in the wake of their destruction, the Xenogenesis Assault Team (XAT) is formed to suppress the threat. Alongside its primary mission to protect against the Amalgam attacks, the organization is also researching the newly discovered "amalgamated" humans which possess rational thought and are far deadlier than their non-sentient counterparts. Joseph Jobson is one such amalgamated human who has full control over his powers. Although successful in his line of work as a lone warrior, an unfortunate encounter with the recently-turned-Amalgam Gerd Frentzen makes him a priority target of the XAT. As he eludes the organization and seeks new allies, Joseph is transformed into the Blassreiter—a being heralded as the strongest Amalgam in existence. Now, he must fight back with his newfound powers to uncover the truth behind not only his past, but also the entire Amalgam conflict. [Written by MAL Rewrite]