After living together for three years, Misaki Takahashi and Akihiko "Usagi" Usami's relationship has been progressing smoothly. However, all great relationships have problems, and theirs is just beginning. With a new rival on the horizon, Usagi worries about Misaki's feelings towards him. Meanwhile, Ryuuichirou Isaka has always loved to intrude on Misaki and Usagi's love life, but his own love life hasn't been all smooth sailing—Isaka and his secretary Kaoru Asahina have been dating for a few years; however, Asahina prefers to keep their professional and private lives separate, often leading to troubled waters between them. As for Nowaki Kusama and Hiroki Kamijou, now that their careers are finally taking off, they hardly see each other anymore. With the time they spend together lessening, doubts and insecurities threaten to creep in between them. On the other hand, the 17-year age gap between Shinobu Takatsuki and You Miyagi has been a constant barrier in their relationship, but as they learn more about each other, their self-consciousness continues to fade. The beloved couples of Junjou Romantica, Junjou Egoist, and Junjou Terrorist are back again, this time with a new addition: Junjou Mistake!

OVAs that come with the limited premium edition of volumes 16 and 20 of the manga series.

Three hundred years ago, in the frigid land of Siberia, Jubei Yagyu engaged in a fierce battle with Kitaretsusai of the Northern Yagyu clan. The duel was costly, as his daughter Freesia was frozen in suspended animation. As a result of global warming in the present day, Freesia breaks free from her icy grave and moves to Japan as a middle school transfer student, where she befriends Jiyuu Nanohana. Little does Jiyuu know that Freesia is targeting her to acquire the coveted Lovely Eye Patch, which Freesia believes is rightfully hers.

In the year 3990, the immortal Oldna Poseidal rules Pentagona, a war-torn solar system of five planets. Daba Myroad is a survivor of the Yaman Clan, just one of numerous native societies nearly wiped out by the tyrant. Living on the remote planet Koam with his friend Mirao Kyao, Daba possesses L-Gaim, a humanoid mecha known commonly as a "Heavy Metal" and the last known relic of the Yaman Clan. The pair befriend Fanneria Amu, an aspiring actress, and Lilith Fau, the last surviving fairy in Pentagona while on the run from a band of thieves attempting to steal L-Gaim. Daba promises to fulfill the dying wish of one of the thieves hunting him—an honorable act that leads him to the powerful merchant Amandara Kamandara. With their mission in sight, the ragtag group will face powerful adversaries and become entangled in a rebellion against Poseidal's reign.