It is 2977 AD and mankind has become stagnant. Robots do all the work, the masses are kept tranquil by subliminal messages, and government officials are lazy, caring only about recreational activities like golf and horse racing. Captain Herlock has defied this insipid mentality, leading a group of like-minded rebels to a more adventurous life aboard the spaceship Arcadia. A mysterious force known as the Mazone has invaded the Earth, taking the form of mysterious cloaked women that kill anyone who suspect their nefarious doings, such as Tadashi Daiba who is now on their hit-list. After his scientist father is ignored by the government and killed by the Mazone, he joins Captain Herlock and his ragtag group of pirates to assist them as they try to save humanity from the impending alien threat. [Written by MAL Rewrite]

An affluent white-collar worker receives a mysterious invitation: "Would you like to know what life is about?" "Would you like to live your life fully?" It is sent into the unpredictable space of the Lord God, and future human beings will invite and challenge the present world, and the different challenges that humans face during the era of great universe development will be simulated as copies as well. The "copies" will guide the selected people to overcome many traps, meet life-and-death comrades, and become leaders. All of this is in the interest of human evolution, survival, and infinite futures!

Time flies by; Hiroyuki and Akari are 12th-graders now. Both of them and their friends have grown up gradually in someway, physically or mentally, but one of their best friends is missing: the lifelike android Multi. To their surprise, Multi is brought to their campus again without notice, yet she is no longer the same Multi they have known.

Third season of Osomatsu-san.