Vash the Stampede is the man with a $$60,000,000,000 bounty on his head. The reason: he's a merciless villain who lays waste to all those that oppose him and flattens entire cities for fun, garnering him the title "The Humanoid Typhoon." He leaves a trail of death and destruction wherever he goes, and anyone can count themselves dead if they so much as make eye contact—or so the rumors say. In actuality, Vash is a huge softie who claims to have never taken a life and avoids violence at all costs. With his crazy doughnut obsession and buffoonish attitude in tow, Vash traverses the wasteland of the planet Gunsmoke, all the while followed by two insurance agents, Meryl Stryfe and Milly Thompson, who attempt to minimize his impact on the public. But soon, their misadventures evolve into life-or-death situations as a group of legendary assassins are summoned to bring about suffering to the trio. Vash's agonizing past will be unraveled and his morality and principles pushed to the breaking point. [Written by MAL Rewrite]

Even though Sasaki's droll corporate life is constantly filled with work, it leaves him tired and unfulfilled at the end of every day. In search of some companionship to fill the emptiness in his life, he visits a pet shop on a whim, not realizing he's about to change his life forever. After settling on an adorable bird and bringing it home...his new roommate reveals that it's actually an incredible sage from another world who promptly bestows Sasaki with supernatural powers as well as the ability to cross between worlds. All Sasaki wants to do is use these newfound powers to live in peace and comfort, but there are more than a few colorful characters who might get in the way of that...

In the senior high school division of Shuchiin Academy, the student council president and vice president, Miyuki Shirogane and Kaguya Shinomiya, appear to be the perfect couple. Kaguya is the daughter of a wealthy conglomerate family, and Miyuki is the top student at the school and well-known across the prefecture. Although they like each other, they are too proud to confess their love, coming up with many schemes to make the other confess.

Yoshino Takigawa, an ordinary teenager, is secretly dating his best friend Mahiro's younger sister. But when his girlfriend Aika mysteriously dies, Mahiro disappears, vowing to find the one responsible and make them pay for murdering his beloved sister. Yoshino continues his life as usual and has not heard from Mahiro in a month—until he is confronted by a strange girl who holds him at gunpoint, and his best friend arrives in the nick of time to save him. Yoshino learns that Mahiro has enlisted the help of a witch named Hakaze Kusaribe to find Aika's killer and of the existence of an entity known as the "Tree of Exodus." The witch's brother selfishly desires to make use of its power, in spite of the impending peril to the world. However, Hakaze is banished to a deserted island, and it is now up to Yoshino and Mahiro to help her save the world, while inching ever closer to the truth behind Aika's death. [Written by MAL Rewrite]