Kimihiro Watanuki's life was never really normal. But in addition to his ability to see spirits, this sequel to xxxHOLiC finds him still slaving away for Yuuko, the bizarre owner of a strange shop, who promised to rid him of this ability. However, this otherworldly woman can only do so when he has worked enough to earn his wish. Such is the way for anyone who finds their way into the shop to have their request granted: a compensation equal to their wish must be paid. In this odd shop that straddles the world of the living and the dead, Watanuki finds himself doing household chores for the seemingly lazy Yuuko and her companions, while also helping out clients. Along with his classmates, supposed romantic rival Shizuka Doumeki and his crush Himawari Kunogi, Watanuki deals with the many misfortunes surrounding Yuuko's customers, as well as those that closely follow him and his friends.

Yachiyo Inugami, a cat-loving extrovert, and Suzu Nekoyama, a dog-loving introvert, are unexpectedly cast into a relationship on a day like any other. The pair find themselves drawn together through an inexplicable attraction of their opposite personalities. As they quickly begin to understand one another, Inugami's hardened resolve to gain Nekoyama's favor only leads to frenzied responses. Soon after their momentous union, the two begin to spend more time with one another, growing closer all the while. Their combined antics gain the attention of the mousy Mikine Nezu, a classmate of Inugami, and soon they join the "biology" club. There, they meet Ushikawa Ukiji, a passive, cow-like upperclassmen. Nezu and Nekoyama soon begin to build upon their relationship and a game of cat and mouse soon begins. Wild, explosive, and vibrant, Inugami-san to Nekoyama-san tells the comedic tale of two high school girls and their less-than-normal relationship. [Written by MAL Rewrite]

Chise is an ordinary schoolgirl: small, frail, and not particularly intelligent. Her greatest joy is her budding romance with her classmate and childhood friend, Shuuji. They both live in a small military town in Hokkaido, where high schoolers have few concerns other than who is dating whom and complaining about the steep climb up "Hell Hill" every day before school. One day, Shuuji and his friends make a trip to Sapporo to buy gifts for their girlfriends. A massive air raid on Sapporo that day kills thousands, including one of Shuuji's friends, and signals the beginning of a war. Fleeing from the carnage, Shuuji spots Chise, though now she has steel wings and a massive gun where her right arm should be. Against her will, she has been transformed into the ultimate cyborg weapon, capable of leveling entire cities. As the war rages closer and closer to their hometown, Chise and Shuuji's relationship is strained by her transformation, and they are left to wonder whether she is even still human. [Written by MAL Rewrite]

A young boy, Gawain, lives in a mountainous, rural area with an incredible love for baseball and making the ball really fly. One day he runs into a visitor to the small area and she introduces him to a sport that can really make a ball take to flight: golf! It just takes one shot and Gawain is hooked. With his grandpa's approval he sets off to Tokyo with this mysterious woman to learn all he can about golf, encountering many colorful characters and obstacles along the way.