In the 21st century, mankind lives on two worlds. Following the collision of an ice asteroid, massive terraforming has made Venus a planet now capable of supporting life. Colonists from Earth tamed the hostile world and have thrived for four generations. But they also brought the darker side of humanity. Venus is about to get hostile again. Hiro Seno, a hotshot motorcycle jockey, witnesses the first strike against his country Aphrodia, by the rival nation of Ishtar. Huge battletanks and warplanes quickly lay waste to the city. The Aphrodian army is quick to mobilize and retaliate... and despite his opposition to warfare, Hiro finds himself fighting for his life on the front lines.

A quiet, polite, lonely immortal esper about which little is known, he is called "Locke the Superman", but often denies being so. It is not known where or when he was born, and if asked, Locke will say he does not remember. It is entirely possible this is true. However, when asked by Cornelia Prim in "Millennium of the Witch" which star he was from, Locke replied "Toa." He has appeared at various times throughout the history of the galaxy, either as a direct influence, an indirect influence, or a simple observer. Using his esper abilities, Locke can learn and do most things more quickly than a normal human. His power also allows him to remain eternally young, or even turn himself into a child again to be adopted by kind-hearted families. It is speculated he remains youthful as an excuse not to take responsibility for whatever cause he is approached for, since no one expects youths to have such responsibilities.

Although already a third-year high school student, Rikka Takanashi remains a chuunibyou—a "disease" that causes people to fantasize about themselves and their surroundings. Her relationship with Yuuta Togashi has also gone unchanged for the past six months, and with entrance exams right around the corner, both of them strive to enroll at the same college. However, Tooka—Rikka's elder sister—decides to take Rikka to Italy as she has found a stable job there. This unforeseen turn of events causes a commotion between the couple as neither of them want to be separated from each other. Desperate for ideas, they seek assistance from their friends, and after a brief conversation, they come up with a plan—to elope. Chuunibyou demo Koi ga Shitai! Movie: Take On Me is a sensational drama featuring the couple—Yuuta and Rikka—as they journey across Japan. The two attempt to prevent Rikka from being taken to Italy, but will they be able to succeed in doing so?

Makoto's grandfather was the principal of the great Onodera Academy, and when he passed away, he left Makoto and his school staff with one very important will - "The one man who is able to seduce Makoto with his superb sexual techniques will be given the right to take over as Onodera Academy's new principal!" Because of this ridiculous last request, Makoto is now every faculty member's target for sexual harassment! Desperate to protect his virginity, Makoto seeks help from his childhood friend (and the man who he has always loved), Kintaro.